Slowing down Cell Division in Pancreas Cancer (IMAGE)

Cold Spring Harbor Laboratory

Slowing down Cell Division in Pancreas Cancer

Caption

Brown staining in these images marks cancerous mouse pancreas cells in which the AKT pathway, which governs protein synthesis, is activated. Upper left: untreated tissue. Lower left: tissue after treatment only with BSO, which reduces antioxidants and thereby increases levels of cellular oxidation; upper right: tissue after treatment with MK2206, a drug that targets the AKT pathway; lower right: tissue after treatment with the team's combination therapy, the AKT inhibitor plus BSO, increasing oxidation. The combination is more effective in inhibiting protein synthesis than either drug administered alone.

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Tuveson Lab CSHL

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