Making Pancreas Organoids to Test New Therapies (IMAGE)

Cold Spring Harbor Laboratory

Making Pancreas Organoids to Test New Therapies

Caption

New knowledge about pancreatic cancer obtained by members of the Tuveson lab was made possible in significant part by their ability to grow pancreas organoids -- spherical accumulations of ductal pancreas cells sampled from living tissue, in which experiments are performed. In this panel of images, tissue reflecting a diversity of states, from healthy to several variants of cancer, are shown along with organoids that they generated. Key: N=normal ductal pancreas tissue; Nn=normal tissue with NRF2 deleted; K=precancerous tissue in which cell bear Kras and p53 are mutated; KPn=malignant tissue in which Kras and p53 are mutated and NRF2 is missing.

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Tuveson Lab, CSHL

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