Evaluation of the Clinically Reported Mutation of the Alpha-5 Chain during Trimer Formation (IMAGE)

Kumamoto University

Evaluation of the Clinically Reported Mutation of the Alpha-5 Chain during Trimer Formation

Caption

(A) Expression of collagen IV alpha-3, alpha-4, and alpha-5 in cells. High luminescence was produced only in the formation of the alpha-345 trimer. (B) Mutant alpha-5 proteins reported in Alport Syndrome had a trimer formation lower than that of the normal type (WT). This suggests that we can evaluate functional abnormalities of collagen IV found in Alport Syndrome using this assay system.

Credit

Dr. Kohei Omachi

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