The Effect of SIRT7 on Osteoblast Differentiation (IMAGE)
Caption
Osteoblasts with reduced expression of SIRT7 show markedly reduced calcification (stained red) compared to normal osteoblasts. Introduction of a mutant SP7/Osterix, which deacylated the 368th lysine of SP7/Osterix, into the osteoblasts that had reduced SIRT7 expression restores most of the calcification.
Adapted from Fig. 6 of Fukuda, M., Yoshizawa, T., Karim, M. F., Sobuz, S. U., Korogi, W., Kobayasi, D., ... Yamagata, K. (2018). SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix. Nature Communications, 9(1). doi: 10.1038/s41467-018-05187-4.
Credit
Dr. Tatsuya Yoshizawa
Usage Restrictions
This image is available under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">Creative Commons Attribution 4.0 License</a>. Any further distribution of this work must maintain attribution to the author(s) and the title of the article, journal citation, and DOI.
License
Licensed content