Figure 1: Complete Retrograde Amnesia (IMAGE)

Japan Science and Technology Agency

Figure 1: Complete Retrograde Amnesia

Caption

Mice were exposed to auditory (7 kHz) fear conditioning. They received injection of phosphate buffered saline (PBS) or anisomycin or anisomycin+tat-beclin (Ani+tBC), after recalling the memory (test 1). PBS-treated mice showed higher freezing response while anisomycin-treated mice showed partial decrease in the freezing response (partial retrograde amnesia), whereas Ani+tBC induced complete retrograde amnesia (test 2). Optogenetic activation of the neurons, storing the 7kHz fear memory, induced freezing in the PBS and anisomycin groups, while the Ani+tBC group continued to show complete retrograde amnesia (test 3).

Credit

Kaoru Inokuchi, Kareem Abdou

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.