Figure 3: Synaptic Plasticity between Engram Assemblies is Necessary for Fear Memory Storage (IMAGE)

Japan Science and Technology Agency

Figure 3: Synaptic Plasticity between Engram Assemblies is Necessary for Fear Memory Storage

Caption

Mice were exposed to two auditory fear conditioning, separated by five hours. Both memories were encoded by shared neurons in the lateral amygdala while they were encoded by different neurons in the auditory cortex. Mice showed freezing behavior in response to 7kHz and 2kHz tones. Induction of optical long term depotentiation (LTD) to synapses specific to 7kHz fear memory, erased only that memory (test 3) without affecting the other memory (test 4) that was stored in shared neuron ensemble.

Credit

Kaoru Inokuchi, Kareem Abdou

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