NSD2 shapes the program of cell senescence (IMAGE)

Kumamoto University

NSD2 shapes the program of cell senescence

Caption

Histone methylation (H3K36me3 barrier) by NSD2 promotes the functions of genes involved in cell proliferation. NSD2 decreases in senescent cells, which causes altered epigenome and gene expression results in loss of cell proliferation and serum response.

Credit

Professor Mitsuyoshi Nakao

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Image is the graphical abstract of <a href="https://onlinelibrary.wiley.com/doi/10.1111/acel.13173">Tanaka et.al. 2020</a>, and is available under the terms of <a href="https://creativecommons.org/licenses/by/4.0/">CC by 4.0</a>. Any further distribution of this work must follow the terms of this license.

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