Figure 2 (IMAGE) Osaka University Caption Specific deletion of PTEN and TRAF3 genes in hepatocytes, but not in cholangiocytes, results in cholangiocyte overgrowth and development of intrahepatic cholangiocarcinoma. Credit © 2022 Yuto Shiode et al., TTraf3 inactivation promotes the development of intrahepatic cholangiocarcinoma via NIKmediated hepatocyte transdifferentiation, Hepatology Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted. License CC BY-NC-ND Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.