Mitochondrial protection mechanism by ketogenesis (IMAGE)

Kumamoto University

Mitochondrial protection mechanism by ketogenesis

Caption

Normal state with HMGCS2 (left) and insufficient ketogenesis with HMGCS2 deficiency (right). Compared with the normal state, the following was observed in the ketogenesis-deficient state: <br> 1. Acetyl CoA, the raw material for ketone bodies, accumulates in the cells. <br> 2. Excessive acetylation of mitochondrial protein (mtP). <br> 3. Dysfunction of the TCA cycle as a result of 1 and 2.

Credit

Dr. Yuichiro Arima

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(Fig. 7f) Reprinted by permission from Springer Nature Customer Service Centre GmbH: Springer Nature, Nature Metabolism, <a href="https://www.nature.com/articles/s42255-021-00342-6" target="_blank">Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation, Yuichiro Arima et. al., 18 February 2021</a> (2021) DOI: 10.1038/s42255-021-00342-6

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