Figure 1: Principle of DNA Base Editors Based on CRISPR (IMAGE)

Institute for Basic Science

Figure 1: Principle of DNA Base Editors Based on CRISPR

Caption

Cytosine base editors (CBE, top) induces C-to-T conversion, and the adenine base editors (ABE, bottom) causes A-to-G conversion. They consist of a guide RNA (green), a Cas9 nuclease (blue) and a base editor (pink), which unite to form a ribonucleoprotein complex. The guide RNA binds the target side on the DNA, while Cas9 cleaves the DNA strand (scissors), and the base editor modifies the desired DNA base, or letter.

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