LSD1 promotes glycolysis and heme synthesis in erythroblastic leukemia (EL) cells (IMAGE)

Kumamoto University

LSD1 promotes glycolysis and heme synthesis in erythroblastic leukemia (EL) cells

Caption

Suppression of LSD1 function (LSD1-KD) inhibits glucose (sugar) uptake into cells (left) and significantly reduces the number of hemoglobin-positive cells (right).

Credit

Associate Professor Shinjiro Hino

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Republished with permission of Elsevier Science & Technology Journals, from <i><a href="https://ashpublications.org/bloodadvances/article/5/9/2305/475840/LSD1-defines-erythroleukemia-metabolism-by">LSD1 defines erythroleukemia metabolism by controlling the lineage-specific transcription factors GATA1 and C/EBP&alpha;</a></i>, Kensaku Kohrogi, Shinjiro Hino, Akihisa Sakamoto, Kotaro Anan, Ryuta Takase, Hirotaka Araki, Yuko Hino, Kazutaka Araki, Tetsuya Sato, Kimitoshi Nakamura, and Mitsuyoshi Nakao, Blood Advances, 5(9), 2021; permission conveyed through Copyright Clearance Center, Inc.?

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