Figure 2. 19F-NMR spectra identifies at least 3 active conformational states (A1, A2, A3) (IMAGE)

Tokyo Institute of Technology

Figure 2. 19F-NMR spectra identifies at least 3 active conformational states (A1, A2, A3)

Caption

19F-NMR spectra identifies at least 3 active conformational states (A1, A2, A3), and an inactive signature, labeled as R above. Binding of receptor to full heterotrimeric G-protein, Gαβγ, significantly increase the population of active states. The receptor adopts a specific active state A1 when it binds both full agonist and G-protein.

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