Figure 3. Computational analysis based on modelling and mathematical rigidity theory (IMAGE)

Tokyo Institute of Technology

Figure 3. Computational analysis based on modelling and mathematical rigidity theory

Caption

Computational analysis based on modelling and mathematical rigidity theory identifies an activation network pathway encompassing the receptor A2AR, the Gβγ subunit, and the Gα subunits of G-protein, harboring the nucleotide (shown in green). Gβγ subunit was discovered to be critical for signalling and sampling of fully active states of receptor resulting in optimal receptor activation.

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Cell

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