インスリン注射剤とD-DNPペプチドの経口共投与による血&# (IMAGE)

Kumamoto University

インスリン注射剤とD-DNPペプチドの経口共投与による血&#

Caption

インスリン注射製剤 (HumulinR3/7) にD体DNPペプチドを添加し、マウスに経口投与したところ、実験で作成した亜鉛インスリン6量体と同様に血糖降下作用が観察された。

Credit

Associate Professor Shingo Ito

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Reprinted with permission from <a href="https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.0c01010" target="_blank"> Ito, S., Torii, Y., Chikamatsu, S., Harada, T., Yamaguchi, S., Ogata, S., ... Ohtsuki, S. (2021). Oral Coadministration of Zn-Insulin with d-Form Small Intestine-Permeable Cyclic Peptide Enhances Its Blood Glucose-Lowering Effect in Mice. Molecular Pharmaceutics. doi:10.1021/acs.molpharmaceut.0c01010</a>. Copyright 2021 American Chemical Society.

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