Hypoglycemic effect of oral coadministration of insulin injection and D-DNP peptide (IMAGE)

Kumamoto University

Hypoglycemic effect of oral coadministration of insulin injection and D-DNP peptide

Caption

When the D-DNP peptide was added to an injectable insulin preparation (HumulinR3/7) and administered orally to mice, a hypoglycemic effect was observed, similar to that of the experimental zinc insulin hexamer.

Credit

Associate Professor Shingo Ito

Usage Restrictions

Reprinted with permission from <a href="https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.0c01010" target="_blank"> Ito, S., Torii, Y., Chikamatsu, S., Harada, T., Yamaguchi, S., Ogata, S., ... Ohtsuki, S. (2021). Oral Coadministration of Zn-Insulin with d-Form Small Intestine-Permeable Cyclic Peptide Enhances Its Blood Glucose-Lowering Effect in Mice. Molecular Pharmaceutics. doi:10.1021/acs.molpharmaceut.0c01010</a>. Copyright 2021 American Chemical Society.

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