Hypomethylation in transcriptional regulatory regions and hypermethylation of genes important for neural function (IMAGE)

Kumamoto University

Hypomethylation in transcriptional regulatory regions and hypermethylation of genes important for neural function

Caption

<p>(Left) The number of hypermethylated DNA regions in both neuronal and non-neuronal cells is reduced in the bipolar patient group (BD) compared to the healthy group (CT). </p> <p>(Right) Methylation status of the BDNF (brain-derived neurotrophic factor) receptor gene (NTRK2), which is important for mental and neurological functions. The upper panel shows the hypermethylated region in patients, and the lower panel shows the DNA methylation status in patients and healthy controls. </p>

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Professor Kazuya Iwamoto

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<p>Left: Fig. 1(b), Right: Fig. 2(d) of <a href="https://www.nature.com/articles/s41380-021-01079-0">Bundo, M. et.al., Molecular Psychiatry, 2021</a>. </p> <p>This image is made available under the terms of <a href="https://creativecommons.org/licenses/by/4.0/">CC by 4.0</a>. Any further distribution of this work must follow the terms of this license. </p>

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