Accumulation of genes with differential DNA methylation status in neurons in GWAS regions (IMAGE)

Kumamoto University

Accumulation of genes with differential DNA methylation status in neurons in GWAS regions

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<p>Researchers performed random sampling of the same number of gene transcriptional control regions in the genome that showed DNA methylation variation 10,000 times to determine the number of matches with GWAS regions for bipolar disorder, major depression and schizophrenia, and to obtain p-values for the measured values (obs). A significant accumulation was found in the GWAS for bipolar disorder, while no significant accumulation was found for major depression or schizophrenia. </p> <p>For each disease, the following data were used. <br> Bipolar disorder: data from Mullins et al, 2020. <br> Major depression: data reported in Howard et al, 2019. <br> Schizophrenia: data from Psychiatric Genomics Consortium, 2014. </p>

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Professor Kazuya Iwamoto

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<p>From Fig. 4(c); column 1, rows 4, 1, & 2 respectively of <a href="https://www.nature.com/articles/s41380-021-01079-0">Bundo, M. et.al., Molecular Psychiatry, 2021</a>. </p> <p>This image is made available under the terms of <a href="https://creativecommons.org/licenses/by/4.0/">CC by 4.0</a>. Any further distribution of this work must follow the terms of this license. </p>

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