Heart Failure Mechanisms Due to Decreased <I>Caren</i> RNA in Cardiomyocytes (IMAGE)
Caption
Caren RNA is abundant in normal cardiomyocytes. It prevents deterioration of cardiac function by enhancing energy production through increased mitochondrial number and inhibiting the activation of the DNA damage response pathways. However, Caren RNA is reduced in cardiomyocytes that are exposed to aging and pressure stress. This leads to mitochondrial dysfunction and activation of the DNA damage response resulting in the development and exacerbation of heart failure.
Credit
Professor Yuichi Oike
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