Figure 5 (IMAGE)

Shinshu University

Figure 5

Caption

The cells in vitro. It is different from the cells in vivo which decrease in number by twelve weeks. In vitro SHOX2 increases. TBX3 decreases slightly. It was hard to understand why, but the environment of the cells in vitro is very different from the cells in vivo. The cells in vitro is 2D, laid out one by one, so to produce cells in an environment closer to in vivo, they cultured the cells 3D. They found that in vitro with the 3D cultured cells, the number of the pacemaker nodal-like cells did not change. So, in conclusion, in vivo (in rats) the nodal-like cells decrease after transplantation but in vitro it does not.

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