レポーターアッセイによるCpG3メチル化の機能的解析 (IMAGE)

Kumamoto University

レポーターアッセイによるCpG3メチル化の機能的解析

Caption

A)CpG部位を人工的にメチル化させ蛍光標識したDNA鎖（レポーターコンストラクト）を神経系細胞株に導入して、発光蛋白質の活性を測定することにより転写活性化能を測定。

B)メチル化されると転写活性化能は失われ。

Credit

Professor Kazuya Iwamoto

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<p>Adapted from figure 2 of <a href="https://academic.oup.com/schizophreniabulletin/advance-article/doi/10.1093/schbul/sbaa075/5859552">Ikegame, T. et al, 2020</a>. </p> <p>This image is made available under Oxford University Press <a href="https://academic.oup.com/journals/pages/access_purchase/rights_and_permissions/publication_rights">"Rights retained by ALL Oxford Journal authors"</a>. Any further distribution of this work must follow OUP's terms of reuse. </p>

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