Functional Analysis of CpG3 Methylation by Reporter Assay (IMAGE)

Kumamoto University

Functional Analysis of CpG3 Methylation by Reporter Assay

Caption

A) The transcriptional activation ability is measured by introducing a fluorescently labeled DNA chain (reporter construct) artificially methylated at the CpG site into a neural cell line and measuring the activity of the photoprotein.

B) When it is methylated, the transcription activation ability is lost.

Credit

Professor Kazuya Iwamoto

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<p>Adapted from figure 2 of <a href="https://academic.oup.com/schizophreniabulletin/advance-article/doi/10.1093/schbul/sbaa075/5859552">Ikegame, T. et al, 2020</a>. </p> <p>This image is made available under Oxford University Press <a href="https://academic.oup.com/journals/pages/access_purchase/rights_and_permissions/publication_rights">"Rights retained by ALL Oxford Journal authors"</a>. Any further distribution of this work must follow OUP's terms of reuse. </p>

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