Change in DNA Methylation of the SERT Gene (IMAGE)
Caption
A) CpG site where the structure and methylation of the SERT gene were analyzed. Transcription is performed from right to left in the figure, and 5-HTTLPR polymorphism exists in the promoter (transcription initiation) region. Boxes indicate exon regions, black indicates a part that does not encode a protein, and white indicates an exon region that encodes a protein.
B) Comparison of methylation in CpG3 between male bipolar disorder patients (male BD) and healthy male subjects (male CT)
C) Comparison of CpG3 methylation in male schizophrenia (male SZ) and male CT
Credit
Professor Kazuya Iwamoto
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<p>Adapted from figure 1 (A, B, C) of <a href="https://academic.oup.com/schizophreniabulletin/advance-article/doi/10.1093/schbul/sbaa075/5859552">Ikegame, T. et al, 2020</a>. Please note that parts D & E are not included here. </p> <p>This image is made available under Oxford University Press <a href="https://academic.oup.com/journals/pages/access_purchase/rights_and_permissions/publication_rights">"Rights retained by ALL Oxford Journal authors"</a>. Any further distribution of this work must follow OUP's terms of reuse. </p>
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