IARS2 was up-regulated in PDAC tissue and cell lines. (IMAGE)

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IARS2 was up-regulated in PDAC tissue and cell lines.

Caption

(A) Bar plot of IARS2 transcription level in different cancer types. (B) TCGA and GTEx databases showed IARS2 transcription level was higher in tumor tissue compared with normal pancreas tissue. (C) High IARS2 expression linked to shorter overall survival time. (D) Disease free survival time was shortened in high IARS2 expression group. (E) IARS2 transcription level was elevated in grade 3–4 PDAC compared with grade 1–2 PDAC. (F) No difference of IARS2 transcription level was detected among pancreatic cancer at different stages. (G) Alteration of IARS2 in TCGA pancreatic adenocarcinoma cohort. (H) IARS2 mRNA transcription was up-regulated in pancreatic adenocarcinoma cell lines compared with normal cell lines. (I) IARS2 protein expression was elevated in pancreatic adenocarcinoma cell lines. (J) Statistical analysis of IARS2 western blotting results. Grey value of brands was measured by ImageJ and data represented the mean ± standard deviation of three experiments. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. IARS2, isoleucyl-tRNA synthetase 2; PDAC, pancreatic ductal adenocarcinoma.

Credit

Genes & Diseases

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