Mechanistic scheme of IARS2 in promoting PDAC progression. (IMAGE)

Compuscript Ltd

Mechanistic scheme of IARS2 in promoting PDAC progression.

Caption

IARS2 reduces β-catenin phosphorylation at Ser33/37 site, subsequently attenuating its ubiquitination and inhibiting degradation. Accumulated β-catenin translocates into nuclear and regulates the downstream targets genes, which leads to PDAC progression. IARS2, isoleucyl-tRNA synthetase 2; PDAC, pancreatic ductal adenocarcinoma.

Credit

Genes & Diseases

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CC BY-NC-ND

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