The effects of Shh on BMP9-induced ectopic bone formation of MSCs. (IMAGE)

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The effects of Shh on BMP9-induced ectopic bone formation of MSCs.

Caption

Representative bone masses from the ectopic bone formation induced by BMP9 alone or BMP9/Shh of C3H10T1/2 cells and C2C12 cells. (B) 3D reconstruction of bone masses by micro-CT analysis. (C) BV and BV/TV results of bone masses. (a) The results of bone masses formed by C3H10T1/2 cells. (b) The results of bone masses formed by C2C12 cells. (D) Histologic evaluation of retrieved bone masses ( × 200). ∗p < 0.05, ∗∗p < 0.01. BMP9, bone morphogenetic protein 9; BV, bone volume; CM, chondroid matrix; OM, osteoid matrix; Shh, Sonic Hedgehog; TB, trabecular bone; TV, total tissue volume.

Credit

Genes & Diseases

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