TKT controls neuroblastoma cell growth in vitro and in vivo. (IMAGE)
Caption
(A) The growth rate of neuroblastoma cells was significantly reduced after TKT knockdown as detected by the CCK-8 assay. (B) 5-Ethyl-2-deoxyuridine (EdU) assay showed that down-regulation of TKT reduced the growth of neuroblastoma cells. (C) Colony formation assays showed that in neuroblastoma cells, knockdown of TKT in neuroblastoma cells reduced the size of colony formation. (D) Effects on CCND1 and CCND2 protein expression after knockdown of TKT in neuroblastoma cells. (E, F) Subcutaneous tumor formation. TKT knockdown resulted in a reduction in tumor size and weight versus control. (G–J) Effect of TKT on cell cycle progression in neuroblastoma cells detected by flow cytometry.
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Genes & Diseases
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