Microdialysis_graphic abstract (IMAGE)
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The key finding of the study is based on microdialysis catheters, whose ‘screening membrane’ can be penetrated by bacteriophages i.e. viruses. Bacteriophages are used in in vivo phage display to screen peptides so that each virus expresses a specific peptide on its surface. In the study, a microdialysis catheter was placed under the skin wound of a living animal. A peptide library, containing over a billion different peptides, was injected into the bloodstream. Microdialysis was used to collect the peptides that entered the wound tissue probe. It provides an additional selection step to the screening method. According to Professor Tero Järvinen, this ensures an exceptionally good ability to screen billions of potential drug candidates.
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Dr. Toini Pemmari, M.D., Ph.D., Tampere University
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