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The Korea Advanced Institute of Science and Technology (KAIST)

Image 3

Caption

Figure 3. Reconstruction of a dynamic network model for the transition state of colorectal cancer. 

A new technology was established to build a gene network computer model that can simulate the dynamic changes between genes by integrating single-cell RNA sequencing data and existing experimental results on gene-to-gene interactions in the critical transition of cancer. (a). Using this technology, a gene network computer model for the critical transition of colorectal cancer was constructed, and the distribution of attractors representing normal and cancer cell phenotypes was investigated through attractor landscape analysis (b-e).

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KAIST Laboratory for Systems Biology and Bio-Inspired Engineering

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