Figure 1 (IMAGE)

Institute for Basic Science

Figure 1

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The “onion model” illustrates how the one-by-one inactivation of the DNA repair pathways brings about changes in TMZ-induced mutational signatures. Every “leaf” of the onion represents the cell line and the graph illustrates the classes of single nucleotide substitutions caused by TMZ. The outer layer is a normal human cell and the second layer is the TMZ-sensitive tumor. Note how different are the TMZ mutational signatures in these two cell types.

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Institute for Basic Science

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