Figure 2 (IMAGE)

Institute for Basic Science

Figure 2

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The survival curves of different DNA repair mutants treated with increasing TMZ concentrations. In this graph, the WT (green) is the TMZ-sensitive tumor. The blue lines are the MMR-deficient mutants, which are a hundred times more resistant than the WT line. Note how knockout of XRCC1 and APE1 genes restores the TMZ sensitivity of the MMR mutants.

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Institute for Basic Science

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