Serum-free culture for HSC induction from hemogenic endothelial cells (IMAGE)

Kumamoto University

Serum-free culture for HSC induction from hemogenic endothelial cells

Caption

This study successfully reproduced the developmental process of hematopoietic stem cells (HSCs) in an in vitro culture system using commercially available endothelial cell lines as feeder cells, without the serum. By adding just two signaling molecules, stem cell factor (SCF) and thrombopoietin (TPO), the researchers were able to induce transplantable HSCs.

Credit

Saori Morino-Koga, Minetaro Ogawa, Kumamoto University

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