The mechanism of HSC development (IMAGE) Kumamoto University Caption The pre-HSCs (HSC progenitors) are stimulated by SCF derived from endothelium in the dorsal aorta, but not by TPO. After migrating to the fetal liver, pre-HSCs receive both SCF and TPO signals, allowing them to differentiate into mature HSCs. Credit Saori Morino-Koga, Minetaro Ogawa, Kumamoto University Usage Restrictions Only to be used in content reporting on this research. Credit must be given to the creator. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.