(IMAGE)

Kumamoto University

Caption

The pre-HSCs (HSC progenitors) are stimulated by SCF derived from endothelium in the dorsal aorta, but not by TPO. After migrating to the fetal liver, pre-HSCs receive both SCF and TPO signals, allowing them to differentiate into mature HSCs.

Credit

Saori Morino-Koga, Minetaro Ogawa, Kumamoto University

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