Cellular plasticity (IMAGE)
Caption
Cellular plasticity across different scales. (A) Schematics showing that 1) the collective plastic response of cells leads to tissue plasticity at macroscopic scales; 2) formation and scission of membrane vesicles result in irreversible deformation of individual cells; 3) various proteins participate in the initiation and pinching of endocytic vesicles at the subcellular scale. (B) Illustration of the multiscale model where cells are treated as tightly packed hexagons at the tissue level; cell-cell junctions are modelled as springs connecting corresponding vertices at the cellular level; and the activation of signalling molecules (triggered by optical/mechanical stimuli), as well as recruitment of myosin motors to the cell junction, are considered at the subcellular scale. (C) Summary of key processes involved in the development of cellular and tissue plasticity.
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The University of Hong Kong
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