(IMAGE)

Tokyo Medical and Dental University

Caption

PD-1+CD8+ T cells were activated rather than exhausted. PD-1+CD8+ T cells infiltrated muscle tissues. Affected muscles reacted to IFNγ, which could be produced from effector T cells, as a danger signal and then expressed PD-L1. Muscles countered PD-1+CD8+ T cell attacks through the enhancement of PD-L1 expression.

Credit

Department of Rheumatology, TMDU

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.