PD-1/PD-L1 pathway in the pathophysiology of idiopathic inflammatory myopathies (IMAGE)

Tokyo Medical and Dental University

PD-1/PD-L1 pathway in the pathophysiology of idiopathic inflammatory myopathies

Caption

PD-1+CD8+ T cells were activated rather than exhausted. PD-1+CD8+ T cells infiltrated muscle tissues. Affected muscles reacted to IFNγ, which could be produced from effector T cells, as a danger signal and then expressed PD-L1. Muscles countered PD-1+CD8+ T cell attacks through the enhancement of PD-L1 expression.

Credit

Department of Rheumatology, TMDU

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