Type IV as an independent prognostic risk factor for HCC with particular transcriptional characteristics. (IMAGE)
Caption
Type IV as an independent prognostic risk factor for HCC with particular transcriptional characteristics. (A, B) Kaplan-Meier curves for OS for patients with type IV tumours versus type I/II/III tumours in indicated cohort (log-rank test). (C, D) Kaplan-Meier curves for RFS for patients in type IV group versus type I/II/III group in indicated cohort (log-rank test). (E, F) Forest map showing multivariate Cox-regression analysis of risk factors for OS and RFS. (G) Dot plot showing GO cellular component enrichment analysis of upregulated DEGs in each gross type. (H) GSEA based on mRNA expression of type I tumours versus corresponding non-tumours using hallmark gene sets (p<0.05). (I) GSEA using hallmark gene sets based on mRNA expression of type IV tumours versus related non-tumours (p<0.05). (J–L) GSEA plots of the indicated signature for type IV tumours versus type I/II/III tumours. (M) Simplify enrichment analysis based on downregulated DEGs between tumour tissues and non-tumour tissues among the four types in current HCC cohort as well as in published ICC cohorts (TCGA-CHOL and GSE32879). (N) Heatmap for mRNA expression of genes involved in indicated tumour microenvironment signatures raised by Bagaev A among the four gross subtypes.17 DEGs, differentially expressed genes; FDR, false discovery rates; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; ICC, intrahepatic cholangiocarcinoma; IPTW, inverse probability of treatment weight; NES, normalised enrichment score; OS, overall survival; RFS, recurrence-free survival.
Credit
By Fan Z, Jin M, Zhang L, et al.
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