Gross classification guiding HCC therapy. (IMAGE)
Caption
Gross classification guiding HCC therapy. (A) H&E staining of HCC tumour samples of all gross types. (B) The Kaplan-Meier curves of OS in patient with type IV HCC treated with or without TACE postoperatively in current overall cohort or IPTW cohort (log-rank test). (C) The Kaplan-Meier curves of OS in patient with type I/II/III HCC treated with or without TACE postoperatively in the overall cohort or IPTW cohort (log-rank test). (D) The Kaplan-Meier curves of OS and PFS in patient with type I/II/III HCC treated with or without adjuvant drug therapies postoperatively in the overall cohort or IPTW cohort (log-rank test). (E) Gd-EOB-DTPA MRI for the patient with HCCs with type III and type IV before and after immunotherapy combined with antiangiogenesis targeted therapy. White arrows indicated HCC nodules. (F) The clinical implementation process for gross classification of resectable HCC and the corresponding recommended treatment strategies. (G) A novel trichotomous classification system, margin morphology classification (MMC) was proposed based on the conventional gross classification. (H) OS or RFS of patients undergoing hepatic resection for HCCs with different MMC subtype (log-rank test). HCC, hepatocellular carcinoma; IPTW, inverse probability of treatment weight; OS, overall survival; RFS, recurrence-free survival; TACE, transcatheter arterial chemoembolisation.
Credit
By Fan Z, Jin M, Zhang L, et al.
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CC BY-NC