Therapeutic opportunities at the intersection of neuroscience and cancer biology (IMAGE)
Caption
Increased understanding of nervous system-cancer crosstalk is beginning to elucidate therapeutic targets for a variety of cancers. While these targets vary in a tumor-specific manner, examples are shown here of the target structure or principle (green), a relevant molecular target (yellow), and of a drug or drug class that may prove useful for therapy (orange). Please note that only examples are shown, and each target is not necessarily relevant for every tumor type; for instance, targeting AMPAR-mediated synapses using the anti-seizure medication parampanel has to date only been demonstrated as a potential strategy for gliomas. Each therapeutic strategy requires testing in prospective clinical trials, which has been initiated for several of these examples (see text).
Credit
Winkler F, Venkatesh HS, et al. Cell 186, April 13, 2023
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License
CC BY-NC