Interaction of Cancer stem cells and macrphages compared with cancer non-stem cells (IMAGE)

Hokkaido University

Interaction of Cancer stem cells and macrphages compared with cancer non-stem cells

Caption

(Top) Cancer stem cells produce interleukin-6 (IL-6), which induces senescence in macrophages (Mφ). In turn, these produce arginase-1 and  inactivate T cells. As a result, cancer cells are not killed by immune system cells, leading to tumor formation. (Bottom) Non-cancer stem cells do not produce IL-6. Macrophages do not age and T cells are activated. Activated T cells destroy cancer cells, preventing tumor formation. (Illustration: Haruka Wada).

Credit

Haruka Wada

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