Aging often brings metabolic troubles, and a new study in Engineering may explain why. Scientists found a special sugar-modified antibody called fucosylated IgG builds up in aging fat tissue. It worsens inflammation and scarring while weakening fat’s normal function. This discovery points to a new way to ease age-related metabolic problems by adjusting this antibody’s sugar structure, giving fresh hope for healthy aging.

B lymphoma remains tough to treat with current cell therapies due to high costs and limited antigen targeting. A new study in Engineering compares two live-cell glycocalyx engineering methods to boost immune cells against B lymphoma. By equipping NK and CAR-T cells with CD22-targeting glycans, researchers enhance tumor recognition and killing. This transgene-free strategy offers a practical, cost-efficient path to better adoptive cell therapies.

Chinese herbal medicines have given birth to many classic drugs, but their complex ingredients and unclear mechanisms slow new drug development. A new study in Engineering proposes phenotype–target coupled drug screening, combining phenotype-based and target-based discovery with AI, multiomics, and organ-on-chip models. This efficient framework helps locate active compounds, clarify targets, and boost success rates for herbal drug research and development.

Struggling with hysteresis and slow computing in high-speed nano-positioning systems? A new study in Engineering presents a neural-network-based switching controller paired with an FPGA–CPU dual-layer framework to tackle these issues. Designed for piezoelectric nano-stages, the approach stabilizes tracking under switching reference signals and supports reliable nanoscale manipulation. Verified by experiments, it delivers improved precision for precision manufacturing and detection tasks.

Soil salinity threatens global farmland, but a new Engineering study offers a sustainable solution. Researchers found that delivering halotolerant plant growth-promoting bacteria through drip irrigation greatly eases salt stress for jujube trees. This method cuts soil salinity, lifts yield and fruit quality, reshapes beneficial soil bacteria, and boosts plant stress resistance. It’s a practical, low-cost way to support crops in saline soils.