Mount Sinai launches AI small molecule drug discovery center
Business Announcement
Updates every hour. Last Updated: 30-Apr-2025 00:08 ET (30-Apr-2025 04:08 GMT/UTC)
The Icahn School of Medicine at Mount Sinai has launched the AI Small Molecule Drug Discovery Center, a bold endeavor that harnesses artificial intelligence (AI) to revolutionize drug development. The new Center will integrate AI with traditional drug discovery methods to identify and design new small-molecule therapeutics with unprecedented speed and precision. Unlike conventional drug discovery, which can take years and cost billions, AI-driven approaches enable researchers to rapidly navigate a vast chemical landscape, including natural products, to pinpoint promising drug candidates. By leveraging Mount Sinai’s world-leading expertise in machine learning, chemical biology, and biomedical data science, the Center aims to bring innovative treatments to patients faster—particularly for diseases with urgent unmet needs, including cancer, metabolic disorders, and neurodegenerative diseases.
A wife and husband professor team at Michigan State University are collaborating with researchers at the University of California, Riverside to create a new light-activated “smart” bomb to treat aggressive breast cancer.
Sophia Lunt, an MSU professor in biochemistry and molecular biology in the College of Natural Science, and Richard Lunt, an MSU professor and Johansen-Crosby Endowed Professor in Chemical Engineering in the College of Engineering, along with Vincent Lavallo, a professor of chemistry at the University of California, Riverside, have combined their expertise to help develop new light-sensitive chemicals called cyanine-carborane salts that are used in photodynamic therapy, or PDT, to destroy metastatic breast cancer tumors in mice with minimal side effects.
The National Comprehensive Cancer Network (NCCN)—an alliance of leading cancer centers—celebrated 30 years of helping people with cancer to live better lives during the NCCN 2025 Annual Conference, March 28-30 in Orlando, Florida. The yearly event brings together leading minds and subject matter experts in front of a multidisciplinary audience to share the latest recommendations for cancer treatment and prevention.
The immune-related genes in the colorectal cancer (CRC) microenvironment are closely associated with patient prognosis and the efficacy of immunotherapy. Professor Wang's group established a novel machine learning-based model to predict prognosis and immunotherapy responses in colorectal cancer (CRC) patients. The authors integrated clinical and transcriptomic data using machine learning techniques and established the Immune Response-related Risk Score (IRRS) model in CRC. The IRRS model is based on 13 core immune-related genes from machine learning techniques, and demonstrates strong associations with tumor progression, immune infiltration, and therapy response. The IRRS model outperforms several existing tools, offering a more accurate and clinically relevant approach to personalized cancer treatment.
Unchanged since 1996, Sweden's hexavalent chromium exposure limit is higher than in several other countries. A research study from Lund University in Sweden shows that even workers exposed to levels of chromium below the Swedish limit display significant cell changes long before cancer develops. A proposal from the Swedish Work Environment Authority to lower the limit has now been put forward.
A team of researchers developed a novel tool to help understand consumer behavior at the county level, and to study the relationship between where people shop for their food and the risk of obesity-related cancers. Their findings are published in BMC Medicine.
A “weekend warrior” approach to physical activity — getting 150 minutes of moderate-to-vigorous physical activity over one to two days instead of throughout the week — improved health and lowered the risk of death, finds a new study in the Journal of the American Heart Association.
CNIO researchers discover that, in mice that eat a lot of fat, cancer cells travelling through the blood surround themselves with platelets, which act as an armor-like protection as they spread.
In addition, in animals with a fatty diet it is easier for tumor cells to 'nest' in other organs and give rise to metastasis of the primary tumor.
“These results anticipate a future in which dietary changes, together with the control of platelet activity, will complement antitumor treatments,” says Héctor Peinado, of the Spanish National Cancer Research Center (CNIO).
The study is published in 'Nature Communications’.