https://doi.org/10.1016/j.apsb.2022.10.015
This new article publication from Acta Pharmaceutica Sinica B, discusses click chemistry and drug delivery.
Click chemistry has been proven to be very useful in drug delivery. Due to the availability of many click reactions with various characteristics, selection of appropriate chemistry for a given application is often not a trivial task. This article gives an overview of available click reactions organized by application types. Further, the general understanding of click reactions being fast and high yielding sometimes overshadows the need to analyze reaction kinetics in assessing suitability of a given reaction for certain applications. The authors highlight the need to analyze the relationship among reaction kinetics, concentration effects, and reaction time scales, knowing that lack of such analysis could easily lead to failures. Further, possible issues such as chemical stability with various click reagents are also discussed to aid experimental designs. Recent examples and extensive references are also provided to aid in-depth understanding of technical details. This article helps those interested in using click chemistry in drug delivery to select the appropriate reactions/reagents and minimize the number of pitfalls.
Keywords: Bioorthogonal chemistry, Bond-breaking reaction, PROTAC, Antibody–drug conjugates, Gasotransmitters
Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S2211383522004403-ga1_lrg.jpg
Not all click reactions have the same fast reaction rate. Careful attention to reaction kinetics is needed in selecting appropriate reactions for a given application.
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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
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CiteScore: 15.9
Impact Factor: 14.907
JIF without self-citation: 13.885
ISSN 2211-3835
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Article reference: Shameer M. Kondengadan, Shubham Bansal, Ce Yang, Dongning Liu, Zach Fultz, Binghe Wang, Click chemistry and drug delivery: A bird's-eye view, Acta Pharmaceutica Sinica B, Volume 13, Issue 5, 2023, Pages 1990-2016, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2022.10.015