PHILADELPHIA – The American Association for Cancer Research (AACR) today announced its newly elected class of Fellows of the AACR Academy.
The mission of the AACR Academy is to recognize and honor distinguished scientists whose scientific contributions have propelled significant innovation and progress against cancer. Fellows of the AACR Academy serve as a global brain trust of top contributors to cancer science and medicine who help advance the mission of the AACR to prevent and cure all cancers through research, education, communication, collaboration, science policy and advocacy, and funding for cancer research.
All Fellows are nominated and elected through an annual, multi-step peer review process that involves a rigorous assessment of each candidate’s scientific accomplishments in cancer research and cancer-related sciences. Only individuals whose work has had a significant and enduring impact on cancer research are considered for election and induction into the AACR Academy.
“We are proud to announce the election of 23 new Fellows of the AACR Academy. These individuals from across the world have all made significant and groundbreaking contributions to cancer research,” said Margaret Foti, PhD, MD (hc), chief executive officer of the AACR. “The 2023 class of Fellows includes pioneers from numerous scientific disciplines who have collectively shaped our understanding and treatment of cancer. We are deeply honored to have them join our 289 existing Fellows and look forward to celebrating their extraordinary scientific achievements at our upcoming Annual Meeting.”
The members of the 2023 class of Fellows of the AACR Academy are:
Carolyn R. Bertozzi, PhD
The Baker Family Director of Sarafan ChEM-H, the Anne T. and Robert M. Bass Professor in the School of Humanities and Sciences, Professor of Chemistry and, by courtesy, of Chemical and Systems Biology and of Radiology, Stanford University; Investigator, Howard Hughes Medical Institute, Stanford, California
For visionary contributions to the Nobel Prize-winning development of click chemistry through the invention of bioorthogonal chemistry; for profiling alterations in cell surface glycosylation associated with cancer, inflammation, and bacterial infection; and for spearheading the development of novel therapeutic modalities for immuno-oncology.
Stephen J. Chanock, MD
Director, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
For pioneering efforts dedicated to defining detectable clonal mosaicism and for impactful research focused on the discovery and characterization of cancer susceptibility regions in the human genome, directly enhancing our understanding of the association between inherited genetic variants and cancer risk.
George Coukos, MD, PhD
Director, Department of Oncology, Lausanne University Hospital; Director, Lausanne Branch, Ludwig Institute for Cancer Research, Lausanne, Switzerland
For seminal contributions to characterizing the occurrence of spontaneous immune responses in ovarian tumors, for demonstrating that tumor-infiltrating lymphocytes may function as strong predictors of enhanced ovarian cancer survival, for identifying fundamental mechanisms regulating T-cell infiltration in cancers and the regulatory function of the tumor endothelial barrier, and for designing and implementing rational immunotherapy clinical trials leveraging the above mechanisms.
Hugues de Thé, MD
Professor, Chair of Molecular and Cellular Oncology, Collège de France, Paris, France
For unparalleled investigations into identifying the molecular drivers of promyelocytic leukemia and developing targeted and curative treatments involving retinoic acid and arsenic that have radically transformed the clinical management of this disease.
Julian Downward, PhD
Principal Group Leader and Associate Research Director, The Francis Crick Institute, London, United Kingdom
For pioneering research leading to the discovery of the epithelial growth factor receptor as the ErbB oncogene product, paving the way for development of drugs targeting EGFR and ErbB2/HER2 in lung, colon, and breast cancers; and for defining RAS/RAF and RAS/PI3K signaling pathways as critical drivers of cancer cell growth.
Laura J. Esserman, MD, MBA
Alfred A. de Lorimier Endowed Chair in General Surgery, University of California, San Francisco (UCSF); Professor, Departments of Surgery and Radiology; Director, UCSF Breast Care Center; Co-Leader, Breast Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California
For steadfast commitment to breast cancer research; her pivotal role as the architect of the Athena Breast Health Network, which gave rise to the WISDOM study, a trial of annual vs. personalized screening and prevention that has enrolled over 50,000 women; for the development of new and improved methods to classify tumor subtypes and determine optimal treatment escalation and/or de-escalation; and for visionary leadership of the I-SPY2 adaptive neoadjuvant platform trial for women with stage 2/3 breast cancer—the longest-running platform trial in cancer—which has tested 24 agent combinations over 12 years.
Keith T. Flaherty, MD
Professor of Medicine, Harvard Medical School; Director of Clinical Research, Dana-Farber/Harvard Cancer Center, Massachusetts General Hospital, Boston, Massachusetts
For groundbreaking translational discoveries and seminal contributions to the development of vemurafenib and other therapeutic agents for the treatment of melanoma, translating investigations of the BRAF V600E somatic mutation in cancer into effective therapies, including the FDA-approved five-drug series for melanoma.
Andy Futreal, PhD
Professor and Chair, Department of Genomic Medicine, Division of Cancer Medicine; Vice President, Strategic Translational Programs; Sheikh Mohamed Bin Zayed Al Nahyan Distinguished University Chair in Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas
For unrivaled research efforts involving large-scale systematic cancer genomics that identified breast and ovarian cancer susceptibility genes and multiple human cancer genes, notably the landmark discovery of BRAF mutations in melanoma—a discovery that led to the development and rapid approval of the first effective targeted therapy for advanced melanoma.
Judy Lieberman, MD, PhD
Professor of Pediatrics, Harvard Medical School; Endowed Chair in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts
For fundamental research contributions to the field of cancer immunology that have contributed to understanding cytotoxic T lymphocytes, key effector cells in antitumor immunity; for the discovery of T-cell exhaustion in humans; and for innovative work describing the molecular basis of inflammatory cell death (pyroptosis) that is immunogenic and may be exploited to enhance antitumor immunity.
Patricia M. LoRusso, DO, PhD (hc)
Professor of Medicine (Medical Oncology); Chief, Experimental Therapeutics; Associate Cancer Center Director, Experimental Therapeutics, Yale Cancer Center and Smilow Cancer Hospital, New Haven, Connecticut
For unrivaled clinical cancer research contributions including expertly and extensively designing and executing innovative early-phase clinical trials; and for improving therapeutic outcomes to not only reduce mortality rates, but also enhance the quality of life for patients with cancer.
Luis F. Parada, PhD
Member, Cancer Biology and Genetics Program, Sloan Kettering Institute; Albert C. Foster Chair; Director, Brain Tumor Center, Memorial Sloan Kettering Cancer Center; American Cancer Society Research Professor; Professor, Cell and Developmental Biology Program, Weill Cornell Graduate School of Medical Sciences, New York, New York
For illuminating research contributions involving the integration of molecular genetics, embryonic development, and signal transduction to understand nervous system tumors; and for pioneering the development of mouse models specifically designed for the investigation and development of glioblastoma multiforme therapies.
Dana Pe’er, PhD
Chair and Professor, Computational and Systems Biology Program, Sloan Kettering Institute; Scientific Director, Alan and Sandra Gerry Metastasis & Tumor Ecosystems Center, Memorial Sloan Kettering Cancer Center; Investigator, Howard Hughes Medical Institute, Professor, PhD Program of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine Graduate School of Medical Sciences, New York, New York
For fundamental contributions to the development of computational methods and algorithms that, when combined with high throughput experimental techniques, have provided key insights into the impact of genetic aberrations on molecular networks responsible for the onset and progression of various cancer malignancies.
Charles M. Perou, PhD
The May Goldman Shaw Distinguished Professor of Molecular Oncology; Co-Director of the Computational Medicine Program; Co-Director of the UNC Lineberger Breast Cancer Research Program; Professor, Department of Genetics, University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
For laudable research contributions that have led to the identification of intrinsic breast cancer subtypes, including the basal-like/triple-negative breast cancer subtype; and for the development of clinical diagnostic tests that are now widely used to stratify breast cancer patients based on the molecular characteristics of their tumors.
Helen Piwnica-Worms, PhD
Professor of Experimental Radiation Oncology, Department of Experimental Radiation Oncology; Senator A.M. Aikin Jr. Distinguished Chair; American Cancer Society Research Professor, The University of Texas MD Anderson Cancer Center, Houston, Texas
For outstanding efforts dedicated to the identification of protein kinases and phosphatases that regulate CDK1; the discovery that Wee1 directly phosphorylates and inhibits CDK1, revealing that CHK1 can be targeted by the synthetic derivative of staurosporine, UCN-01; and for the discovery of signaling pathways involving 14-3-3 proteins responsible for cell cycle checkpoint control.
Thomas M. Roberts, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Professor, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts
For instrumental contributions to elucidating the tyrosine kinase signaling pathways critical for tumorigenesis, with particular emphasis on PI3K; and for ushering in the age of precision medicine through fundamental discoveries of signaling mechanisms capable of regulating cell growth, knowledge that has been subsequently applied to the development of transformative cancer therapies.
Erkki Ruoslahti, MD, PhD
Distinguished Professor Emeritus, Sanford Burnham Prebys, La Jolla, California
For paramount discoveries involving the mechanisms of cellular adhesion; for the co-discovery of fibronectin, the discovery of the fibronectin RGD cell attachment sequence, homing peptides, and tumor-penetrating peptides; and for the development of therapeutics for vascular thrombosis and cancer.
Michel Sadelain, MD, PhD
Member, Immunology Program, Sloan Kettering Institute; Stephen and Barbara Friedman Chair; Director, Center for Cell Engineering, Memorial Sloan Kettering Cancer Center; Professor, PhD Program of Immunology and Microbial Pathogenesis, Weill Cornell Medicine Graduate School of Medical Sciences, New York, New York
For unparalleled contributions to the conceptualization and optimization of chimeric antigen receptor (CAR) T cells, including engineering CARs that provide enhanced proliferation, survival, and potency to T cells, identifying CD19 as a target for CAR therapy, and designing CD19 CAR therapies for patients with relapsed, refractory acute lymphoblastic leukemia.
Kevan M. Shokat, PhD
Professor and Vice Chair, Department of Cellular and Molecular Pharmacology, University of California, San Francisco; Investigator, Howard Hughes Medical Institute, Chevy Chase, Maryland; Professor of Chemistry, University of California, Berkeley, Berkeley, California
For revolutionary discoveries in the field of chemical genetics, including pioneering work to develop the first covalent inhibitors of KRAS G12C capable of therapeutically targeting a once-undruggable oncogene, which led to clinical trials involving various cohorts of lung, colon, and pancreas cancer patients and which notably expanded the armamentarium of available agents to combat cancer.
Andreas Strasser, PhD
Division Head, Division of Blood Cells and Blood Cancer, WEHI (Walter and Eliza Hall Institute of Medical Research), Parkville, Victoria, Australia
For trailblazing research devoted to identifying connections between apoptosis, autoimmunity, and cancer, including genetic studies that established BCL-2-related BH3-only proteins as being vital for inducing mitochondrial apoptosis; and for demonstrating that dysregulation of apoptosis can lead to cancer, autoimmune disease, and impaired therapeutic responses in cancer cells.
Jean Y. J. Wang, PhD
Distinguished Professor Emeritus, Department of Medicine and Biology, University of California San Diego School of Medicine, La Jolla, California
For critical research that has been vital to elucidating the mechanisms by which cells respond to various intracellular and extracellular stimuli, including how cancer cells manage to evade such signals to avoid cell death; and for efforts to define the various cellular functions of the c-Abl tyrosine kinase proto-oncogene and the retinoblastoma tumor suppressor protein.
Robert A. Winn, MD
Director and Lipman Chair in Oncology, Virginia Commonwealth University Massey Cancer Center; Senior Associate Dean, Cancer Innovation; Professor, Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia
For heralded contributions to lung cancer research, cancer and health disparities, and community-based health care, including characterizing the molecular mechanisms that drive cellular proliferation and the role of senescence in lung cancer; and for dedicated efforts to champion health equity and access to care among underserved, high-risk cancer populations.
Jedd Wolchok, MD, PhD
Meyer Director, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine; Professor of Medicine, Co-Director, Ludwig Collaborative Laboratory, Weill Cornell Medicine, New York, New York
For illustrious contributions to novel cancer immunotherapy strategies, such as demonstrating the benefits of checkpoint inhibitor therapy in melanoma; and for leading several pivotal clinical trials, including the phase I clinical trial for ipilimumab and the phase III clinical trial involving the combination of ipilimumab and nivolumab.
Catherine J. Wu, MD
Professor of Medicine, Dana-Farber Cancer Institute and Harvard Medical School; Chief, Divisionof Stem Cell Transplantation and Cellular Therapies, Dana-Farber Cancer Institute; Institute Member, Broad Institute of Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts
For groundbreaking discoveries involving immunogenic antigen targets; for developing genomic-guided immunotherapy and neoantigen-targeting cancer vaccines; and for translating these research findings into early-phase clinical trials designed to ascertain the clinical viability of personalized tumor vaccines in melanoma and glioblastoma patients.
AACR ACADEMY ELECTS NEW PRESIDENT
The Fellows of the AACR Academy have elected Elizabeth M. Jaffee, MD, FAACR, as their next President. She will assume the presidency during the AACR Annual Meeting 2023, to be held April 14-19 at the Orange County Convention Center in Orlando, Florida.
Jaffee is the Dana and Albert “Cubby” Broccoli Professor in oncology and deputy director of the Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins University, as well as inaugural director of the Convergence Institute and associate director of the Bloomberg~Kimmel Institute for Cancer Immunotherapy at SKCCC. She is also a professor of pathology at the Johns Hopkins University School of Medicine, codirector of the Skip Viragh Center for Pancreas Cancer Clinical Research and Patient Care, and deputy director of the Johns Hopkins Institute for Clinical and Translational Research.
Jaffee was inducted into the AACR Academy in 2018 and served as AACR President for the 2018-2019 term. She was recently announced as the recipient of the 2023 AACR-Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research in recognition of her exceptional leadership, outstanding record of service to the cancer community, and brilliant scientific discoveries.