Exercise helps against insulin resistance in the brain

If the brain no longer responds correctly to the hormone insulin (insulin resistance), this also has a negative effect on the metabolism in the body and the regulation of eating behavior. A recent study shows that as little as eight weeks of exercise can help restore the brain's insulin sensitivity in severely overweight adults. This opens up new therapeutic possibilities for reducing obesity and diabetes risk factors in the future. The study by the DZD, Tübingen University Hospital and Helmholtz Munich has now been published in JCI Insight.

Fourteen women and seven men aged 21-59 years with a body mass index* of 27.5 - 45.5 took part in the study. Functional magnetic resonance imaging (MRI) was used to determine insulin sensitivity in the brain before and after eight weeks of monitored endurance training.

Eight weeks of exercise improved insulin sensitivity

The result: the exercise program improved insulin action in the brain to the level of a person with a healthy weight. "The exercise intervention increased the insulin-stimulated activity in brain regions that are responsible, among other things, for the perception of hunger and satiety and for the interaction of motivation, reward, emotion and exercise behavior," said DZD scientist PD Dr. Stephanie Kullmann, who works at the Institute of Diabetes Research and Metabolic Diseases (IDM) of Helmholtz Munich at the University of Tübingen and the Department of Diabetology and Endocrinology at Tübingen University Hospital. The improved insulin sensitivity in the brain had positive effects on the metabolism, the sensation of hunger decreased and the unhealthy visceral fat was reduced.

Possible new starting point for therapies against obesity and diabetes

"The study suggests that insulin resistance in the brain may be reversible and could be a viable therapeutic target to restore central nervous system regulation of metabolism and body weight and counteract adverse effects of obesity," said Professor Martin Heni, last author of the study. To verify whether improving brain insulin sensitivity in people at high risk of T2D actually has beneficial effects on metabolism and cognition, further controlled intervention studies are planned. They can also help clarify the underlying mechanisms.

Original Publication:
Stephanie Kullmann, … , Cora Weigert, Martin Heni et al.: Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese. JCI Insight. 2022;7(18):e161498. https://doi.org/10.1172/jci.insight.161498.

Scientific Contact:

PD Dr. Stephanie Kullmann

Institute of Diabetes Research and Metabolic Diseases (IDM) of Helmholtz Munich at the University of Tübingen
Otfried Müller Straße 47
72076 Tübingen
Germany

Phone: +49 7071 29 87703

Prof. Dr. Martin Heni
Ulm University Hospital – Section for Endocrinology and Diabetology
Albert-Einstein-Allee 23
89081 Ulm
Germany

Phone: +49 731 500 44505

*Body-Mass-Index

 The body mass index, or BMI for short, is a formula for evaluating body weight and is used to estimate the body fat percentage. For the calculation of the BMI (body mass index), the body weight is set in relation to body height. The BMI is calculated from the quotient of body weight and height squared (kg/m²). Depending on the level of the value calculated, a distinction is made between the different categories: underweight (below 18.5), normal weight (18.5 to 24.9), overweight (25 to 29.9), extreme overweight (obesity grade 1: 30 to 34. 9), obesity grade 2 (35 to 39.9) and obesity grade 3 (over 40).

1) Kullmann et al. (2020): Brain insulin sensitivity is linked to adiposity and body fat distribution. Nature Communications, DOI: doi.org/10.1038/s41467-020-15686-y