High blood pressure speeds up mental decline, but does not fully explain dementia disparities

People with high blood pressure levels face a faster erosion of their ability to think, make decisions and remember information than those with normal blood pressure levels, a new study finds.

The researchers traced high blood pressure’s association with declining brain function over years, in data from six large studies that they pooled and analyzed. They show that blood pressure-related cognitive decline happens at the same pace in people of Hispanic heritage as in non-Hispanic white people.

The team had set out to see if differences in long-term blood pressure control explained why Hispanic people face a 50% higher overall risk of dementia by the end of their life than non-Hispanic white people in the United States.

But the new findings suggest that other factors may play a bigger role in that disparity.

Nevertheless, the new study in the Journal of Alzheimer’s Disease serves as an important reminder of the key role that controlling blood pressure plays in long-term brain health, says Deborah Levine, M.D., M.P.H., lead author of the study and director of the University of Michigan’s Cognitive Health Services Research Program.

“Our findings suggest that high blood pressure causes faster cognitive decline, and that taking hypertension medication slows the pace of that decline,” says Levine, a professor of internal medicine at the U-M’s academic medical center, Michigan Medicine.

“Since other studies have shown that people of Hispanic heritage in the United States tend to have higher rates of uncontrolled hypertension than non-Hispanic white people, due in part to worse access to care, it’s vital that they get extra support to control their blood pressure even if blood pressure is only part of the picture when it comes to their higher dementia risk,” she adds. “A risk factor like uncontrolled high blood pressure that is more prevalent in one group can still contribute to substantial health disparities.”

Levine and her colleagues looked at changes in the thinking and memory abilities of adults over 18 who took part in six long-term studies conducted over the past five decades. On average, they had access to nearly eight years of data from each person, including systolic blood pressure, which is the top number in any blood pressure reading.

The size of the data set allowed them to trace blood pressure readings and changes on tests of cognitive performance, executive function and memory in Hispanic and non-Hispanic white adults more clearly than any one smaller data set could.

The data come from 22,095 non-Hispanic white adults and 2,475 Hispanic adults, none of whom had a history of stroke or dementia when they enrolled. At enrollment, the average systolic blood pressure was lower in Hispanic adults than non-Hispanic white adults (132.5 mmHg compared with 134 mmHg), despite Hispanic adults having older age than non-Hispanic adults (62 versus 54) and blood pressure tending to increase with age.

Overall, the downward trend in thinking and memory due to high blood pressure happened at the same pace in both groups.

When Levine and colleagues looked just at the two studies that had deliberately recruited people of Hispanic origin, they saw a faster decline in overall cognitive performance in the Hispanic group compared with the non-Hispanic white group.

But differences in blood pressure between the groups did not explain the differences in cognitive decline -- perhaps because Hispanic people had lower blood pressure than the non-Hispanic white people in these studies.

Levine notes that the studies included data on years of education. But they did not include full information about factors known as social determinants of health – including income, education quality, early life experiences, family factors, living circumstances and more — that might drive disparities in cognitive decline between Hispanic and non-Hispanic white people.

Two years ago, members of the study team reported on their findings from a similar analysis of data from Black and White people in some of the same studies. That study found that differences in blood pressure control over time helped explain the faster decline in cognitive performance in Black individuals.

Levine and colleagues at the U-M Frankel Cardiovascular Center are currently studying other aspects of cognitive decline disparities, including her own team’s research on post-stroke cognitive declines, and Lewis Morgenstern, M.D., M.S.’s BASIC Cognition study. Having a stroke can increase the risk of dementia fifty-fold, but it is not known yet what impact controlling vascular risk factors such as blood pressure and blood sugar can have on dementia risk after stroke.

Additional authors: Alden L. Gross; Emily Briceño; Nicholas Tilton; Rachael Whitney; Dehua Han; Bruno Giordani; Jeremy Sussman; Rodney Hayward; James F. Burke; Mitchell S. Elkind; Andrew E. Moran;  Sarah Tom; Rebecca Gottesman; Darrell J. Gaskin; Stephen Sidney; Kristine Yaffe; Raph L. Sacco; Susan R. Heckbert; Timothy M. Hughes; Oscar L. Lopez; Norrina Bai Allen; Andrzej T. Galecki

Funded by the National Institute of Neurological Disorders and Stroke (R01 NS102715; PI, Levine D)

Blood Pressure and Later-Life Cognition in Hispanic and White Adults (BP-COG): A Pooled Cohort Analysis of ARIC, CARDIA, CHS, FOS, MESA, and NOMAS, Journal of Alzheimer's Disease, vol. 89, no. 3, pp. 1103-1117, 2022, DOI: 10.3233/JAD-220366, https://content.iospress.com/articles/journal-of-alzheimers-disease/jad220366