Air pollution exposure may heighten risk of heart disease among US adults receiving hemodialysis

In a study published in the American Journal of Kidney Diseases (AJKD), researchers found that US adults receiving hemodialysis with higher levels of air pollution exposure have more heart attacks and strokes compared to those with low levels of exposure; strongest associations of air pollution exposure with cardiovascular events were noted among patients who were Asian, older, or had chronic lung disease at dialysis initiation.  

Long-term exposure to air pollution, also called PM_2.5, has been linked to adverse cardiovascular (CV) outcomes. However, little is known about the association of PM_2.5 and outcomes among patients receiving dialysis, individuals with high CV disease burdens. Led by Yuzhi Xi, researchers conducted an epidemiological study to assess the association between the annual PM_2.5 exposure and CV events and death among patients receiving regular outpatient hemodialysis in the United States between 2011-2016. They found a higher risk of heart attacks, strokes, and related events in patients exposed to higher levels of air pollution. Stronger associations between air pollution and adverse health events were observed among patients who were older at the start of dialysis, had chronic obstructive pulmonary disease, or were Asian. These findings bolster the evidence base linking air pollution and adverse health outcomes and may inform policy makers and clinicians. Exposure mitigation on the individual-level could be beneficial to at-risk individuals. Future studies should be conducted to study additional air pollutants’ (Ozone, NO_x, etc.) potential health impact among such vulnerable populations.

ARTICLE TITLE: Association Between Long-term Ambient PM_2.5 Exposure and Cardiovascular Outcomes Among US Hemodialysis Patients

AUTHORS: Yuzhi Xi, PhD, David B. Richardson, PhD, Abhijit V. Kshirsagar, MD, MPH, Timothy J. Wade, PhD, Jennifer E. Flythe, MD, MPH, Eric A. Whitsel, MD, Ana G. Rappold, PhD 

DOI: 10.1053/j.ajkd.2022.04.008

Full text of article: https://www.ajkd.org/article/S0272-63862200706-5/fulltext (Open Access)