Dual functions of the Interleukin-1 Receptor-Like 2 Cytokine

The Interleukin-1 Receptor-Like 2 (IL-1RL2) cytokine can promote inflammatory diseases and have a role in controlling infection. The receptor can recognize multiple agonists and has been implicated in the development of inflammatory diseases such as psoriasis and inflammatory bowel disease (IBD). A comprehensive review of IL-1RL2 is published in the peer-reviewed Journal of Interferon & Cytokine Research (JICR). Click here to read the article now.

O. Medina-Contreras, from Mexico Children’s Hospital, and coauthors, review the many implications of IL-11RL-2, also known as IL-36 in the skin, lungs, and gut. They discuss its ability to promote the expression of inflammatory cytokines and chemokines and its role in infection, including a potential role in COVID-19 pathology.

“It seems that the IL-36IL-1RL2 axis has both inflammatory and healing functions, probably depending on other mediators in the extracellular milieu and the stage of the infection,” state the investigators. “There is still much to discover about this recently described cytokine family, its functions in other organs, and how it accomplishes a dual effect in both inflammation and healing.”

“This is a fascinating review that highlights the importance of IL-36-IL-1RL2 in the development of several inflammation-related diseases and the healing process. The paper is an excellent example of the innovative and cutting-edge research published in the journal,” says Journal of Interferon & Cytokine Research Editor-in-Chief David L. (Woody) Woodland, PhD.

About the Journal
Journal of Interferon & Cytokine Research (JICR) is an authoritative peer-reviewed journal published monthly online with open access options and in print that covers all aspects of interferons and cytokines from basic science to clinical applications. Journal of Interferon & Cytokine Research is an official journal of the International Cytokine & Interferon Society. Complete tables of content and a sample issue may be viewed on the JICR website.

About the Publisher
Mary Ann Liebert, Inc., publishers is known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s more than 100 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.