Stem Cell Delivery Routes: From Preclinical Models to Clinical Applications covers current knowledge about stem cell delivery for cell-based therapeutics. Starting with an introduction to stem cell technology, the book provides information about the main mesenchymal stem cell (MSC) delivery routes and the cell carrier materials used for delivering the cells. The main delivery routes include the liver, the kidney and the ocular surface. This introductory information is followed up with general information about stem cell based therapeutics, covering relevant topics such as the secretome and optimal delivery strategies in cell-based therapeutics. The book then progresses into the topic of in vivo cell tracking methods in preclinical and clinical studies with specific emphasis on the liver, ocular surface and kidney while also covering factors that affect the residence time, viability, and homing of MSCs with respect to the targeted location. The discussions in these chapters are accompanied by key descriptions of MSC-based therapeutic applications in rodent models and human clinical studies. The advantages and bottlenecks in clinical MSC application, and ways to improve the therapeutic efficacy of transplanted cells are also presented, rounding up the contents of the book.
The contents are adapted to suit readers learning about advanced stem cells therapies at all academic levels, including undergraduates, lecturers, as well as those who are curious to understand more about the importance of stem cells, and their application in cell-based therapeutics. Professionals involved in allied fields in clinical research, and biomedical engineering will also gain a substantial understanding about regenerative medicine and cell transplantation.
Audience: undergraduates, lecturers, clinical researchers, biomedical engineers (medicine, tissue engineering) and general readers interested in stem cells, and their application in cell-based therapeutics.
About the Editor/ Author:
Dr. Sharmila Fagoonee (Ph.D.) is a researcher at the Institute of Biostructure and Bioimaging of the Italian National Research Council (CNR) and Molecular Biotechnology Center in Turin, Italy. After her B.Sc. (Hons.) in Biology in Mauritius and M.Sc. in Cellular Biology in Bordeaux, France, she got her Ph.D. in Human Cell and Molecular Biology at the University of Turin. Her Ph.D. thesis was centered on analyzing heme and hemoglobin metabolism in mice models. During her post-doc studies, she started working in the field of regenerative medicine, especially on embryonic stem cells and spermatogonial stem cells and their differentiative capacity, after attending a training at BIDMC, Harvard, Boston, USA. Using in vitro and in vivo multidisciplinary approaches, her two current research areas are: 1) Regenerative Medicine: the investigation of the potential of adult stem cell-based therapy for human pathologies in preclinical models and the search for extracellular vesicles-based disease biomarkers and 2) Post-transcriptional regulation of gene expression: finding the molecular mechanisms underlying the role of the RNA binding proteins and splicing factors, ESRPs, in human diseases. She is a coordinator of internships, a scientific committee member, and a lecturer of the Master’s course in Stem Cells, Regenerative Medicine, and Cell Factory Management at the University of Turin. Dr. Fagoonee is the chief editor of Minerva Biotecnologica (Minerva Biotechnology and Biomolecular Research) journal and is active as an Editorial Board member as well as a reviewer of several scientific journals. She is the author and co-author of over 200 scientific publications and 5 book chapters.
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