image: During bouts of neural ischemic such as those occurring in diabetic retinopathy and retinopathy of prematurity, a program of cellular senescence is triggered. Senescent cells then adopt a senescence-associated secretory phenotype that compromises the tissue microenvironment. Pictured is the mouse retinal vasculature (red) that becomes senescent (blue) and contributes to retinal disease progression. Retinal microglia are in yellow. This material relates to a paper that appeared in the Oct. 26, 2016, issue of Science Translational Medicine, published by AAAS. The paper, by M. Oubaha at Université de Montréal in Montreal, Quebec, Canada, and colleagues was titled, 'Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.' view more
Credit: Sapieha Lab, Maisonneuve Rosemont Hospital, Université de Montréal